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Essentials of Pharmaceutical Preformulation
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Essentials of Pharmaceutical Preformulation

Publication Year: 2012
Edition: 1st
Authors/Editor: Gaisford, Simon; Saunders, Mark
Publisher: Wiley
ISBN: 978-0-470-97635-7
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A study guide which describes the basic principles of pharmaceutical physicochemical characterization.

Successful preformulation requires knowledge of fundamental molecular concepts (solubility, ionisation, partitioning, hygroscopicity and stability) and macroscopic properties (physical form, such as the crystalline and amorphous states, hydrates, solvates and co-crystals and powder properties), familiarity with the techniques used to measure them and appreciation of their effect on product performance, recognising that often there is a position of compromise to be reached between product stability and bioavailability.

This text introduces the basic concepts and discusses their wider implication for pharmaceutical development, with reference to many case examples of current drugs and drug products. Special attention is given to the principles and best-practice of the analytical techniques that underpin preformulation (UV spectrophotometry, TLC, DSC, XRPD and HPLC). The material is presented in the typical order that would be followed when developing a medicine and maps onto the indicative pharmacy syllabus of the Royal Pharmaceutical Society of Great Britain

  • Platform:
    Ovid
  • Publisher: Wiley
  • Product Type: Book
  • Author/Editor: Gaisford, Simon; Saunders, Mark
  • ISBN: 978-0-470-97635-7
  • Specialty:
    Pharmaceutical Science
    Pharmacology
  • Language: English
  • Edition: 1st
  • Pages: 268
  • Illustrations: 0
  • Year: 2012

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