Home > Books > Streptomyces in Nature and Medicine: The Antibiotic Makers
Streptomyces in Nature and Medicine: The Antibiotic Makers
View PDF

Streptomyces in Nature and Medicine: The Antibiotic Makers

Publication Year: 2007
Edition:
Authors/Editor: Hopwood, David A.
Publisher: Oxford University Press (OUP)
ISBN: 978-0-195-15066-7
  • Description
  • Details

This is an insider's account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs.

The book begins by describing how these microbes--the actinomycetes--were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use.

The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.

  • Platform:
    Ovid
  • Publisher: Oxford University Press (OUP)
  • Product Type: Book
  • Author/Editor: Hopwood, David A.
  • ISBN: 978-0-195-15066-7
  • Specialty:
    History of Medicine/Science
    Infectious Diseases
    Medical Genetics
    Microbiology
  • Language: English
  • Edition:
  • Pages: 272
  • Illustrations: 50
  • Year: 2007

Free Instant Access
This Month

JOTM
CAB Abstracts The most comprehensive database for applied life sciences, CAB Abstracts gives researchers instant access to over 8.4 million records, with over 360,000 abstracts added each year.
JOTM
Evidence-Based Medicine Reviews (EBMR) A definitive resource for electronic information in the evidence based medicine movement that combines the most trusted resources into a single, fully-searchable database.
JOTM
Continuum: Lifelong Learning in Neurology Helps practicing neurologists to improve patient care, stay abreast of advances in neurology, and develop lifelong, self-directed learning and critical thinking skills.
JOTM
Journal of Healthcare Management Offers timely articles that inform and guide executives, managers, educators, and researchers. It contains regular columns by experts and practitioners on trending topics.

Noteworthy

Doody's Featured Books
The 5-Minute Clinical Consult 2019
A practical, highly organized resource for clinicians in primary care, family medicine, emergency medicine, nursing, and pediatrics. Provides rapid access to guidance on diagnosis, treatment, medications, follow-up, and associated factors for more than 540 diseases and conditions.

Evidence-Based Geriatric Nursing Protocols for Best Practice
This new edition of one of the premier references for geriatric nurses in hospital, long-term, and community settings delivers current guidelines, real-life case studies, and evidence-based protocols developed by master educators and practitioners.