Home > Books > MIF: Most Interesting Factor
MIF: Most Interesting Factor
View PDF

MIF: Most Interesting Factor

Publication Year: 2007
Edition: 1st
Authors/Editor: Bucala, Richard
Publisher: World Scientific Publishing Co, Inc.
ISBN: 978-9-812-70648-5
Doody's Star Rating®:  Score: 85
  • Description
  • Details

In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF.

Topics covered in the text include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.

  • Platform:
  • Publisher: World Scientific Publishing Co, Inc.
  • Product Type: Book
  • Author/Editor: Bucala, Richard
  • ISBN: 978-9-812-70648-5
  • Specialty:
  • Language: English
  • Edition: 1st
  • Pages: 332
  • Illustrations: 0
  • Year: 2007
  • Doody's Star Rating®:  Score: 85

Free Instant Access
This Month

Evidence-Based Medicine Reviews (EBMR) A definitive resource for electronic information in the evidence based medicine movement that combines the most trusted resources into a single, fully-searchable database.
Global Health The only specialist bibliographic abstracting and indexing database dedicated to public health and capturing key literature that is not covered by other databases.
Clinical Orthopaedics and Related Research® Original articles highlighting the latest in clinically relevant basic science of musculoskeletal diseases and their treatments.
Annals of Internal Medicine Published by the American College of Physicians, contains original articles, case reports, topical reviews, editorials, book reviews and medical notices for internal medicine.


Doody's Featured Books
Osborn's Brain: Imaging, Pathology, and Anatomy
Covers the must-know aspects of brain imaging together with spectacular pathology examples, relevant anatomy, and up-to-date techniques in neuroradiology.

Neurology Evidence: The Practice-Changing Studies
Synthesizes the vast body of literature available in neurology into one accessible, clinically relevant volume-features papers that have had the most impact on changing clinical practice.