Home > Books > Growth Factors and Psychiatric Disorders (Novartis Foundation Symposium 289)
Growth Factors and Psychiatric Disorders (Novartis Foundation Symposium 289)
View PDF

Growth Factors and Psychiatric Disorders (Novartis Foundation Symposium 289)

Publication Year: 2008
Edition: 1st
Authors/Editor: Novartis Foundation
Publisher: Wiley
ISBN: 978-0-470-51604-1
  • Description
  • Details

The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms.

Recent studies have substantiated the provocative finding that neuregulin 1 (NRG1)is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development of the cardiovascular and nervous systems. Lack of NRG1 function may be involved in dysregulation of synaptogenesis and synaptic plasticity in the adult mediated through glutamate receptor function. Polymorphisms for BDNF (brain-derived neurotrophic factor) have also been implicated in the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic factor that plays an important role in the pathophysiology of depression, bipolar disease and other psychiatric disorders.

Other topics addressed in this book include neuroplasticity and neurotrophic factors, signal transduction by neurotrophins, intracellular trafficking of growth factors, trophic factors and cognitive functions, neurotrophins and depression, and pharmacological treatments of schizophrenia.

  • Platform:
    Ovid
  • Publisher: Wiley
  • Product Type: Book
  • Author/Editor: Novartis Foundation
  • ISBN: 978-0-470-51604-1
  • Specialty:
    Psychiatry
  • Language: English
  • Edition: 1st
  • Pages: 258
  • Illustrations: 0
  • Year: 2008

Free Instant Access
This Month

JOTM
Ovid Emcare A premium nursing and allied health database ideal for practice, research, or education. Uncover evidence-based literature and the latest scientific advancements that support patient treatment and lead to more cost-effective and higher quality care.
JOTM
Maternity and Infant Care A key information resource used by maternity health care professionals and student midwives worldwide to support their research, practice, and study requirements.
JOTM
The American Journal of Nursing (AJN) Peer reviewed and evidence-based, AJN is the oldest and most honored broad-based nursing journal in the world. Considered the profession’s premier journal with numerous awards for excellence in editing and dissemination, including several award-winning series.
JOTM
Journal of Cardiovascular Nursing Official journal of the Preventive Cardiovascular Nurses Association, provides thorough coverage of timely topics and information that is extremely practical for daily, on-the-job use.

Noteworthy

Doody's Featured Books
Lippincott Manual of Nursing Practice, 11th Edition
A classic nursing reference, the fully updated 11th Edition, offers expert nursing knowledge and much-needed practical guidance on patient care.

Lippincott Visual Nursing: A Guide to Diseases, Skills, and Treatments, 3rd Edition
This colorful book for practicing nurses and nursing students provides a unique approach to learning important clinical concepts and techniques.