Home > Books > Critical Pathways to Success in CNS Drug Development
Critical Pathways to Success in CNS Drug Development
View PDF

Critical Pathways to Success in CNS Drug Development

Publication Year: 2010
Edition: 1st
Authors/Editor: Cutler, Neal R; Sramek, John J.; Murphy, Michael F; Riordan, Henry; Biek, Peter; and Carta, Angelico
Publisher: Wiley
ISBN: 978-1-444-33064-9
  • Description
  • Details
  • Collections

Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials

The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials.

The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future.

Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed.

Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations

  • Platform:
    Ovid
  • Publisher: Wiley
  • Product Type: Book
  • Author/Editor: Cutler, Neal R; Sramek, John J.; Murphy, Michael F; Riordan, Henry; Biek, Peter; and Carta, Angelico
  • ISBN: 978-1-444-33064-9
  • Specialty:
    Pharmacology
  • Language: English
  • Edition: 1st
  • Pages: 272
  • Illustrations: 0
  • Year: 2010

Critical Pathways to Success in CNS Drug Development is included in the following Collections:

Free Instant Access
This Month

JOTM
Ovid® Emcare A premium nursing and allied health database ideal for practice, research, or education. Over 5 million bibliographic records derived from over 3,700 international, unembargoed journals.
JOTM
Maternity and Infant Care A key information resource used by maternity health care professionals and student midwives worldwide to support their research, practice, and study requirements.
JOTM
Journal of Nursing Administration JONA is the authoritative source of information on developments and advances in patient care leadership.
JOTM
Journal of the American Association of Nurse Practitioners JAANP provides a strong clinical focus with articles related to primary, secondary, and tertiary care, nurse practitioner education, health policy, ethics, and health care delivery.

Noteworthy

Doody's Featured Books
Manual of Nursing Diagnosis
Outlines the major diagnoses listed by NANDA-I in order to help nurses and students create care plans for patients with any range of ailments.

Critical Care Nursing Made Incredibly Easy!®
This comprehensive reference is a must-have for class use and NCLEX or certification exam preparation—and an invaluable on-the-spot clinical guide.